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基于自解耦三明治结构的横向运动栅场效应晶体管微机电系统微力传感器 Article

高文迪, 乔智霞, 韩香广, 王小章, Adnan Shakoor, 刘存朗, 卢德江, 杨萍, 赵立波, 王永录, 王久洪, 蒋庄德, 孙东

《工程（英文）》 2023年第21卷第2期页码 61-74 doi: 10.1016/j.eng.2022.06.018

摘要：由此设计了一种新型的三明治夹层结构，该结构由跨轴解耦Au-栅极阵列层和两个柔性光刻胶SU-8 层组成。

关键词：微力传感器横向运动栅极场效应管柔性光刻胶SU-8 生物医学显微操作

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Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review

Simin Feng, Xiaoli Zhang, Dunyun Shi, Zheng Wang

《化学科学与工程前沿（英文）》 2021年第15卷第2期页码 221-237 doi: 10.1007/s11705-020-1927-8

摘要： Zeolitic imidazolate framework-8 (ZIF-8), composed of Zn ions and imidazolate ligands, is a class of metal-organic frameworks, which possesses a similar structure as conventional aluminosilicate zeolites. This material exhibits inherent porous property, high loading capacity, and pH-sensitive degradation, as well as exceptional thermal and chemical stability. Extensive research effort has been devoted to relevant research aspects ranging from synthesis methods, property characterization to potential applications of ZIF-8. This review focuses on the recent development of ZIF-8 synthesis methods and its promising applications in drug delivery. The potential risks of using ZIF-8 for drug delivery are also summarized.

关键词： zeolitic imidazolate framework-8 (ZIF-8) synthesis methods applications drug delivery

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面向21世纪的柔性制造技术

邓宏筹

《中国工程科学》 2000年第2卷第9期页码 12-23

摘要：作者从以数控机床应用为基础的柔性制造技术的产生和应用着手，论证了这一发展战略的可行性及其对人类生产发展的历史必然性的顺应。作者对制造业在改革中碰到的一些问题发表了意见，希望有助于讨论和取得共识。

关键词：柔性制造技术数控机床柔性制造单元柔性制造系统柔性自动线

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Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis

null

《医学前沿（英文）》 2015年第9卷第1期页码 72-76 doi: 10.1007/s11684-014-0347-x

摘要：

Periodontitis is an inflammatory disease of the periodontium. Any imbalance between the matrix metalloproteinases (MMPs) secreted by neutrophils and tissue inhibitors initiates the destruction of collagen in gum tissue, leading to chronic periodontitis. This study aimed to correlate salivary levels of MMP-8 and periodontal parameters of chronic periodontitis to establish MMP-8 as a noninvasive marker for the early diagnosis of chronic periodontitis. The study involved 40 subjects visiting the periodontic OPD of Dr. Ziauddin Ahmad Dental College and Hospital, located in Aligarh, U.P., India, from 2011 to 2012. The subjects were divided into two groups: group I consisted of 20 periodontally healthy subjects (controls) while group II consisted of 20 patients with chronic periodontitis. Chronic periodontitis was assessed on the basis of several periodontal parameters, including pocket probing depth (PPD), clinical attachment level (CAL), gingival index (GI), and plaque index (PI). Around 3 ml of unstimulated and whole expectorated saliva was collected for MMP-8 estimation by ELISA using Quantikine human total MMP-8 immunoassay kits. Data were analyzed using STATISTICA (Windows version 6) software. Salivary MMP-8 levels of groups I and II were 190.91±143.89 ng/ml and 348.26±202.1 ng/ml, respectively. The MMP-8 levels and periodontal status (PPD, CAL, GI, and PI) of groups I and II showed positive and significant correlations (for PPD, r = 0.63, P<0.001; for CAL, r = 0.54, P<0.001; for GI, r = 0.49, P<0.001; and for PI, r = 0.63, P<0.001). The results of this study demonstrate elevated concentrations of MMP-8 in individuals with chronic periodontitis.

关键词： matrix metalloproteinase-8 chronic periodontitis pocket probing depth clinical attachment level gingival index plaque index

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复合柔性结构航天器动力学建模研究

曲广吉,程道生

《中国工程科学》 1999年第1卷第2期页码 52-56

摘要：

柔性航天器动力学建模的传统方法是采用混合坐标法，针对中心刚体带大型柔性附件类的航天器，这种方法在理论建模和工程应用方面都获得了极大的成功。在中心刚体加柔性附件类航天器柔性动力学研究成果基础上，通过计及柔性体与柔性体连接点间的复合位移变形，利用混合坐标法建立了复合柔性结构航天器动力学模型，其软件系统DASFA 2.0已初步用于工程分析设计。

关键词：航天器复合柔性结构柔性动力学混合坐标法

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淀粉基API胶合木胶接结构破坏模式及失效机理

时君友,徐文彪,王淑敏

《中国工程科学》 2014年第16卷第4期页码 40-44

摘要：

以淀粉基水性高分子异氰酸酯（API）胶合木胶接结构为研究对象，以胶接的压缩剪切强度为评估指标，通过加速湿热老化试验对胶接结构的破坏模式和失效机理进行了研究结果表明：胶接结构的断裂性质为韧性断裂，且随着老化时间的增加，其破坏模式为由内聚破坏向内聚破坏+界面破坏转变。在湿热老化试验前期温度对压缩剪切试样性能起主要作用，在老化后期湿度起主要作用。

关键词：胶接结构加速湿热老化断裂性质破坏模式

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工程农业柔性管理研究

韩贵清

《中国工程科学》 2012年第14卷第12期页码 48-51

摘要：

工程农业柔性管理是适应农业生产特点将工程管理模式应用于农业生产的一种管理理念。在分析农业生产特征的基础上，结合工业生产理念，提出工程农业柔性管理的内涵，系统分析其维度构成，包括生产力维度、生产者维度和生产关系维度。介绍柔性管理在生产力维度的创新应用，提出提高农民决策素质这一全新概念，并从工程农业柔性管理的视角对国家推进农业生产组织化政策进行理论阐释。

关键词：工程农业柔性管理农民决策素质

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Protective efficacy of vaccination with NcMIC3 and NcMIC8 against

Taotao ZHANG, Xiao ZHANG, Qun LIU, Jianhai XU, Jing LIU

《农业科学与工程前沿（英文）》 2019年第6卷第2期页码 188-196 doi: 10.15302/J-FASE-2019253

摘要：

Microneme proteins (MICs) are important for Apicomplexan parasite invasion due to their adhesion to host cells. Several studies have indicated that MIC3 and MIC8 are important adhesion factors and potential vaccine candidates against neosporosis. In this study, we evaluated the protective efficacy of recombinant proteins and DNA vaccines of NcMIC3 and NcMIC8. BALB/c mice were immunized with rNcMIC3, rNcMIC8, pcDNA3.1-NcMIC3 and pcDNA3.1-NcMIC8 respectively, and challenged with tachyzoites. The immune responses were evaluated through cytokine, antibody measurements and the parasite burden in the mice brain tissues. Serological analysis showed that recombinant protein vaccines induced higher levels of immunoglobulin G (IgG) than other groups. The percentage of IgG1 and IgG2a in the recombinant protein groups was higher than the other groups, and with a predominance of IgG1 over IgG2a, suggesting that recombinant protein vaccines elicited a Th2-type immune response, while DNA vaccines mainly produce a Th1-type immune response. In addition, mice immunized with rNcMIC3 and rNcMIC8 a had lower parasite burden in brain tissue compared with the other groups. These results demonstrate that rNcMIC3 and rNcMIC8 could induce humoral and Th2-type immune response, leading to a considerable level of resistance against neosporosis.

关键词： NcMIC3 NcMIC8 Neospora caninum vaccination

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青岛地铁8号线海底隧道

贺维国, 刘鹏

《工程（英文）》 2018年第4卷第2期页码 167-169 doi: 10.1016/j.eng.2018.03.012

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住宅建筑需求侧柔性——定义、柔性负荷及量化方法 Review

罗正意, 彭晋卿, 曹静宇, 殷荣欣, 邹斌, 谭羽桐, 严晋跃

《工程（英文）》 2022年第16卷第9期页码 123-140 doi: 10.1016/j.eng.2022.01.010

摘要：

本文综述了近年来关于住宅建筑需求侧柔性的定义、柔性负荷及柔性量化方法方面的研究。首先，针对建筑需求侧柔性、运行柔性和能源柔性等不同的术语，进行了系统的比较和区分；其次，对住宅建筑主要柔性负荷的运行特性和柔性能力进行了总结和比较；再次，对柔性负荷的建模方法和柔性量化指标也进行了详细的综述和总结这些柔性负荷在运行特性、使用频率和柔性能力
方面存在较大的差异，而对于它们实际的响应特性有待进一步研究。此外，本文给出了用于柔性负荷建模的白箱、灰箱和黑箱模型在不同应用场合下适用性的建议；对于柔性量化指标，现有研究主要从功率、时间、能量、效率、经济性和环保性等维度提出了大量的指标，但是缺少统一的柔性量化体系本文能够帮助读者更好地理解建筑需求侧柔性、区分与柔性相关的不同的术语、了解住宅建筑不同柔性负荷的运行特性和柔性能力，同时也能为柔性负荷的建模和柔性量化的相关研究提供指导。

关键词：住宅建筑需求侧柔性柔性负荷建模方法量化指标

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8英寸绝缘栅双极型晶体管 (IGBT) 关键技术研究 Article

刘国友,丁荣军,罗海辉

《工程（英文）》 2015年第1卷第3期页码 361-366 doi: 10.15302/J-ENG-2015043

摘要：

基于8英寸绝缘栅双极型晶体管 (IGBT) 生产线的建设，重点解决了8英寸IGBT先进工艺技术、第四代高压双扩散金属氧化物半导体 (DMOS+) IGBT技术和第五代沟槽栅IGBT技术等关键技术问题，实现了高压IGBT芯片制造从6英寸到8英寸的技术突破，自主开发的1600 A/1.7 kV与1500 A/3.3 kV IGBT模块已经被成功制造并通过考核，现已应用于轨道交通牵引系统。

关键词：绝缘栅双极型晶体管 (IGBT) 高功率密度沟槽栅 8英寸轨道交通

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Prohibitin regulates mTOR pathway via interaction with FKBP8

Jiahui Zhang, Yanan Yin, Jiahui Wang, Jingjing Zhang, Hua Liu, Weiwei Feng, Wen Yang, Bruce Zetter, Yingjie Xu

《医学前沿（英文）》 2021年第15卷第3期页码 448-459 doi: 10.1007/s11684-020-0805-6

摘要： The ability of tumor cells to sustain continuous proliferation is one of the major characteristics of cancer. The activation of oncogenes and the mutation or inactivation of tumor suppressor genes ensure the rapid proliferation of tumor cells. The PI3K–Akt–mTOR axis is one of the most frequently modified signaling pathways whose activation sustains cancer growth. Unsurprisingly, it is also one of the most commonly attempted targets for cancer therapy. FK506 binding protein 8 (FKBP8) is an intrinsic inhibitor of mTOR kinase that also exerts an anti-apoptotic function. We aimed to explain these contradictory aspects of FKBP8 in cancer by identifying a “switch” type regulator. We identified through immunoprecipitation–mass spectrometry-based proteomic analysis that the mitochondrial protein prohibitin 1 (PHB1) specifically interacts with FKBP8. Furthermore, the downregulation of PHB1 inhibited the proliferation of ovarian cancer cells and the mTOR signaling pathway, whereas the FKBP8 level in the mitochondria was substantially reduced. Moreover, concomitant with these changes, the interaction between FKBP8 and mTOR substantially increased in the absence of PHB1. Collectively, our finding highlights PHB1 as a potential regulator of FKBP8 because of its subcellular localization and mTOR regulating role.

关键词： prohibitin 1 FKBP8 mTOR cell proliferation cancer

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Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic

《医学前沿（英文）》 2022年第16卷第6期页码 909-918 doi: 10.1007/s11684-021-0890-1

摘要： In patients with acute promyelocytic leukemia (APL), intracranial hemorrhage (ICH), if not identified promptly, could be fatal. It is the leading cause of failure of induction and early death. Thus, biomarkers that could promptly predict severe complications are critical. Here, cytokine differences between patients with APL with and without ICH were investigated to develop predictive models for this complication. The initial cytokine profiling using plasma samples from 39 patients and 18 healthy donors found a series of cytokines that were remarkedly different between patients with APL and healthy controls. The APL patients were subsequently divided into high and low white blood cell count groups. Results showed that tumor necrosis factor α and interleukin 8 (IL-8) were vital in distinguishing patients with APL who did or did not develop ICH. In addition, verification in 81 patients with APL demonstrated that the two cytokines were positively correlated with the cumulative incidence of ICH. Finally, in-vitro and in-vivo experimental evidence were provided to show that IL-8 influenced the migration of APL-derived NB4 cells and impaired the blood–brain barrier in PML/RARα positive blast-transplanted FVB/NJ mice. These assessments may facilitate the early warning of ICH and reduce future mortality levels in APL.

关键词： acute promyelocytic leukemia intracranial hemorrhage cytokines biomarker

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工程承包联营体的柔性分析与评价

赵振宇,殷音

《中国工程科学》 2008年第10卷第9期页码 84-87

摘要：

讨论了工程承包联营体环境动荡性评价指标和工程承包联营体柔性评价指标以及相应的评价方法。通过柔性分析，可以判断出工程承包联营体各方面的柔性程度能否与其相应的环境和内外部因素相适应，并为制订调整联营体柔性度的措施提供帮助，进而提高联营体的管理水平和竞争力。

关键词：工程项目承包商联营体柔性管理

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IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to

《医学前沿（英文）》 2022年第16卷第3期页码 403-415 doi: 10.1007/s11684-021-0858-1

摘要： The morbidity and mortality of myeloproliferative neoplasms (MPNs) are primarily caused by arterial and venous complications, progression to myelofibrosis, and transformation to acute leukemia. However, identifying molecular-based biomarkers for risk stratification of patients with MPNs remains a challenge. We have previously shown that interferon regulatory factor-8 (IRF8) and IRF4 serve as tumor suppressors in myeloid cells. In this study, we evaluated the expression of IRF4 and IRF8 and the JAK2V617F mutant allele burden in patients with MPNs. Patients with decreased IRF4 expression were correlated with a more developed MPN phenotype in myelofibrosis (MF) and secondary AML (sAML) transformed from MPNs versus essential thrombocythemia (ET). Negative correlations between the JAK2V617F allele burden and the expression of IRF8 (P <0.05) and IRF4 (P<0.001) and between white blood cell (WBC) count and IRF4 expression (P <0.05) were found in ET patients. IRF8 expression was negatively correlated with the JAK2V617F allele burden (P <0.05) in polycythemia vera patients. Complete response (CR), partial response (PR), and no response (NR) were observed in 67.5%, 10%, and 22.5% of ET patients treated with hydroxyurea (HU), respectively, in 12 months. At 3 months, patients in the CR group showed high IRF4 and IRF8 expression compared with patients in the PR and NR groups. In the 12-month therapy period, low IRF4 and IRF8 expression were independently associated with the unfavorable response to HU and high WBC count. Our data indicate that the expression of IRF4 and IRF8 was associated with the MPN phenotype, which may serve as biomarkers for the response to HU in ET.

关键词： myeloproliferative neoplasms IRF4 IRF8 hydroxyurea essential thrombocythemia